Measure binding affinity and kinetics in real-time with the inQuiQ

Label-free biosensing that returns K_D, k_a and k_d from 30 µL of sample. Integrated photonics bring multiplex, high-sensitivity interaction data to your own bench.

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Explore the NES technology

One label-free analysis platform for all your binding questions

Engineered Antibodies

Affinity, kinetics, and epitope binning for clone ranking.

Engineered antibodies

Small molecules
& Peptides

Reliable fragment screening and small molecule binding affinity, label-free.

Small molecules and peptides

Molecular Glues
& PROTACs

Protein degraders ternary complex kinetics and molecular glue screening.

Molecular glues and PROTACs

Structural Biology

Binding validation and affinity to complement cryo-EM.

Structural biology

Complex Biological Matrices

Binding analysis in serum, plasma, and crude samples.

Complex biological matrices

Bioprocessing

Active concentration, kinetics, and batch-to-batch comparability.

Bioprocessing

Membrane proteins

GPCR ligand binding, lipid bilayer sensors, and construct comparison.

Membrane proteins

Aggregated Proteins

Characterization of aggregated proteins and protein self-association.

Aggregated proteins

Nucleic acids

Aptamer binding affinity, hybridization kinetics, and sequence specificity.

Nucleic acids

EVs and LNPs

Binding kinetics for extracellular vesicles and lipid nanoparticles.

EVs and LNPs

Label-free interaction analysis, matched to your application

Tell us what you're measuring and we'll tell you whether the inQuiQ fits.

Talk to a specialist

Label-free biosensing for every stage of biomolecular research

From early research to advanced development, get reproducible biomolecular binding data without the complexity of traditional instruments.

The data quality is excellent and highly encouraging. The analytical performance is highly impressive, particularly considering the complexity of the PD-1/PD-L1 interaction studies we do.

Prof. Dr. Norbert Sewald

Organic and Bioorganic Chemistry

PD-1/PD-L1 binding kinetics

Characterization of PD-1/PD-L1 binding, delivering reproducible kinetic measurements with a K_D of 37.7 nM.

From sample to signal
Built around flexible assay setup

The inQuiQ connects flexible sample handling, photonic detection, and real-time data output in a workflow that brings a photonic approach to surface plasmon resonance-style label-free biosensing.

0 1

Sample

Start with the material your lab already has. Purified or crude, filtered through 0.22 µm.

Proteins, antibodies, and peptides
Small molecules and DNA
Serum, plasma, and lysate
EVs and LNPs

0 2

Flexible 4-Channel Setup

Four channels allow users to flexibly run different assays, conditions, references, or experiments.

1Reference

2Analyte 1

3Analyte 2

4Analyte 3

0 3

Label-free detection on a photonic chip

Binding at the surface shifts the local refractive index. The photonic chip reads that shift and turns it into a signal.

0 4

Real-time binding affinity measurement

Translate interaction behaviour into real-time kinetic and affinity insight.

inQuiQ Software - Sensorgram View

Ch 1 Ch 2 Ch 3

One platform, two instruments

The inQuiQ is a modular platform that grows with your needs. For many, 10 samples unattended is enough. But as your needs grow, the inQuiQ can be easily upgraded with an autosampler, increasing the throughput to two 96- or 384 wellplates.

inQuiQ

See binding others miss

Baseline noise typically below 0.1 RU RMS.

For tight and weak binders

Equilibrium dissociation constant from 10 pM to 10 mM.

10 samples, 4 channels, 16 sensors

Flexible assay setup with 4 channels, up to 16 targets with a spotter.

Injections from 30 µL to 2 mL

Both short injections or long contact times.

inQuiQ 768

Modular upgrade path

Extend the inQuiQ with an autosampler as needs grow.

Up to 768 samples, unattended

Two well-plates in one automated run.

Consistent photonic performance

Consistent results your data deserves.

Future ready platform

The benefits of photonics biosensing.

Why labs are moving beyond surface plasmon resonance & bio-layer interferometry

Surface plasmon resonance

Scaling requires a new instrument
Bulky instrument with at least 1 to 24-hour equilibration
Gold chip surface challenging for complex matrix assays
Instrument, service, and specialist cost stacks up

inQuiQ integrated photonics

Modular platform with high-throughput pathway
4-channel flow-cell in a benchtop instrument
Strong small molecule sensitivity and broad application fit
Low cost of ownership with photonic technology

Biolayer interferometry

Dip sensor sensitivity limits weak and small analytes
Increasing throughput requires a new instrument
Only parallel samples, with a single "channel"
Single-use tips make cost per sample climb

Application notes, publications, and data

From antibody affinity to small molecule kinetics, explore real binding data generated on the inQuiQ. Each application note pairs a sensorgram with the affinity and kinetic values behind it.

See all resources

Featured Small Molecule Interactions Kinetic analysis of 250 Da small molecule interactions with Carbonic Anhydrase II using label-free sensing.

whitepaper PD-1/PD-L1 Interaction Real-time, label-free NES analysis characterized PD-1/PD-L1 binding, delivering reproducible kinetic measurements with a KD of 37.7 nM.

whitepaper PD-1/PD-L1 Inhibition with BMS-1166 Label-free analysis quantified BMS-1166 inhibition of PD-1/PD-L1 binding, demonstrating dose-dependent inhibition with an IC₅₀ of 8.2 nM.

whitepaper Biomarker Detection in Complex Clinical Matrix Quantifying biomarkers in complex matrices using label-free optical sensing.

whitepaper Measuring Tight Binders Measuring tight binders with precise, long-term kinetic analysis of biomolecular interactions.

whitepaper DNA-protein interaction analysis Kinetic analysis of DNA-protein interactions using label-free optical sensing.

Technical note High-Throughput Analysis Rapid, high-throughput quantitation of IL-6 using label-free optical sensing in under 3 minutes.

Technical note Chip Reusability and Stability Reproducible biomolecular interaction measurements using reusable, stable sensor chips.

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